BURN - Thermogenic Powder
Core BURN is a comprehensive weight management supplement and appetite suppressants
- 1 scoops per serving.
- 50 servings per container.
BURN is the next innovation in thermogenics. A modern weight loss solution using trademarked and patented ingredients, BURN addresses every major metabolic pathway of adipose creation and deposition. Whereas many thermogenics focus exclusively on stimulation, BURN contains ingredients with specific, high-quality evidence demonstrating their efficacy. SaffSerene™, for example, has been demonstrated to significantly reduce subjective feelings of hunger – one of the only dietary ingredients on the market that the FDA allows to make such a claim. KSM-66®, a patented extract of Ashwagandha, has been shown to significantly reduce corstiol – the body’s key stress hormone – in clinical trials. Together with the other premium ingredients in BURN, these two ingredients create an unparalleled weight management product.
A complete formula, BURN is simply the modern evolution in weight loss supplements. With every facet of weight loss covered, BURN is the perfect companion to your diet and exercise regimen.
SHRED - Non-Stimulant Thermogenic Powder
It’s late evening and you need to crush your workout – worst of all, you're deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
- 1 scoop per serving.
- 56 servings per container.
- Healthy thyroid support.
It’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
Prior to now, you sucked it up and chugged your ultra-potent and effective stimulant-based thermogenic (such as BURN Powder!) and dealt with the consequences. But as of now, you take a scoop of the ultra-potent and equally effective, non-stimulant-based thermogenic Core SHRED.
We’ve taken our typical approach to product formulation – proven ingredients at clinically-effective and clinically-proven serving sizes – and applied it to creating a comprehensive, multiple-pathway non-stimulant thermogenic product. The result is a product covering major pathways of lipolysis in multiple, non-redundant, and synergistic ways, all without any neurological stimulation whatsoever.
Whether you’re taking a break from stimulants, are stimulant sensitive, or simply want a non-stimulant thermogenic to stack with our excellent stimulant-based offerings, Core SHRED is the perfect solution. Use it anytime, night or day, to help crush your regular exercise program and consistent diet!
SEAR - Non-Stimulant Thermogenic and Recomposition Agent
Why do we call it “burning fat”? It is a strange turn of phrase, as the body does not “burn” the adipose tissue (the technical name for “fat”). Of course, heat is involved in the base process of fat metabolism, hydrolysis, but the average person of course does not have this in mind. What the common phrasing captures is that the adipose tissue is now being used for fuel – burned up, as gasoline is burned up in a combustion engine as fuel for the vehicle. In this sense, the phrase “burning fat” captures something essential about the mechanisms of adipose metabolism. One mechanism of increasing this process overall is increasing the conversion of WAT (white adipose tissue) to BAT (brown adipose tissue) – known as the “browning” of fat.
It is precisely this mechanism that Core SEAR affects. There are many pathways to enhance lipolysis, the process by which stored triglycerides – the “stuff” of fat tissue – are broken down to release their potential energy into actual energy. One of the most effective is modulating the enzymes that interconvert WAT (white adipose tissue, which stores energy) to BAT (brown adipose tissue, which releases energy) and the chemical and enzymatic cascades that induce lipolysis. SEAR addresses both. Sinetrol XPur®, a blend of citrus fruit extracts, and MitoBurn™, a metabolite of L-valine, have been demonstrated to increase white-to-brown adipose tissue conversion and therefore the resultant energy expenditure increase. Meanwhile, Coleus forskholli and Paradoxine® have been shown to heavily influence cellular communication and enzymatic pathways involved in lipolysis, specifically the cAMP and AMPk pathways.
Together, this simple but incredibly powerful formula earns its name: searing white into brown adipose tissue and increasing your body’s energy expenditure due to fat metabolism.
BURN - Thermogenic Powder
Acetyl-l-Carnitine:
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.
Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
KSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)
Withania somnifera Dunal, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, Withania somnifera is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.
Recently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.
In recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).
The high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:
- A 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.
- Statistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.
- Increased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.
- Statistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.
Though each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).
To put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!
Garcinia cambogia fruit extract (50% hydroxycitric acid):
Garcinia cambogia, more commonly known under a variety of names, including the tamarind, is a small tropical fruit endemic to Indonesia. This plant has come under increased media attention over the past few years, due largely to the purported effects of its principal constituent, hyrdoxycitric acid, or HCA.
HCA itself is a derivative of citric acid, and competitively inhibits the enzyme adenosine triphosphatase-citrate-lyase. This enzyme is an extra-mitochondrial enzyme (meaning it sits outside the mitochondria) chiefly responsible for a process known as de novo lipogenesis – or the production of fatty acids from glucose.
Green coffee extract (50% chlorogenic acid):
Chlorogenic acids are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea’s constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.
Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.
Trials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the product’s numerous mechanisms of action, rather than a single, isolated cause.
Yerba Mate Extract 4:1 (Ilex paraguariensis)(leaf)
Yerba Mate, otherwise known by its scientific name Ilex Paraguariensis, is a flowering tree with leaves rich in polyphenols, saponins and xanthines. The metabolic effectiveness of Yerba Mate has been studies on both fatty acid oxidation (FAO) as well as energy expenditure derived FAO (EEFAO). A recent study showed that supplementing Yerba Mate paired with sub-maximal exercise increased fat utilization by 23%. Another study concluded that Yerba Mate increase FAO and EEFAO by 24% in exercise intensities below 70% and even more profound FAO when exercising below 50% of exercise intensity.
Caffeine (1,3,7-trimethylxanthine) and Theobromine (3,7-dimethyl-1H-purine-2,6-dione):
Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.
Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source for the oxidative provision of ATP (your body’s energy currency).
Evidence for caffeine’s capacity as a lipolytic is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.
Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.
Bacopa monnieri (50% bacosides):
Bacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.
More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.
Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN Ultra formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or, “crash.”
Züm-XR ® XR Caffeine (provides 50mg caffeine):
Züm-XR is a patented coating technology that allows the dissolution profile of certain ingredients, primarily caffeine, to have a longer lasting affect in blood serum levels. The release of those ingredients is initiated by an abrasion in the stomach and pH levels between the stomach and the upper gastrointestinal tract. The coating of the microbead technology is a patented timing system with pharmaceutical grade safe polymers. Comparatively speaking, the dissolution profile of Züm-XR caffeine to your typical immediate release caffeine showed that Züm-XR took a far greater amount of time, well over 120 minutes to complete the process of dissolution.
Saffron Extract (stigma) (Crocus sativus L.) (SaffSerene ™):
SaffSerene ™ patented Saffron is a deviate from non-GMO saffron flowers source from Turkey and Morocco. This particular Saffron extract contains 2% safronal, crocin, and pirocrocin as primary active constituents. Saffron has been used in ancient folk medicine as a sedative, antidepressant, etc. A randomized double-blind placebo controlled trial conducted in 2005 between 30 female and male testers suggested that a moderate and consistent dose of saffron significantly benefited mood after 6 weeks. Furthermore, a pilot trial conducted in 2004 evaluated the effectiveness of Saffron comparatively to Fluoxetine. In a minimal dose of 15mg daily, the consistency of saffron compared to fluoxetine was overwhelmingly positive in regards to alleviating acute depression and anxiety. In addition it has been suggested that crocin and safranal inhibit repute of dopamine, norepinephrine and serotonin levels.
SHRED - Non-Stimulant Thermogenic Powder
Acetyl-l-Carnitine:
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
Olive Extract (Oleaeuropaeai) (leaf) (20% oleuropein):
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research inanimals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Coleus forskohlii root extract (20% forskolin):
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SHRED!
CapsiAtra®:
CapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.
CapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.
The thermogenic and lipolytic effects of capsinoids, like capsaicin itself, are mediated by the Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the mouth and throughout the gastrointestinal tract. TRPV1 receptors in the gut are linked with the sympathetic nervous system (SNS). When activated, they increase SNS activity (the figure below). TRPV1 receptors present on the tongue and in the oral cavity are responsible for, among other things, detection of thermal heat. When capsaicin binds to oral TRPV1 sites, one feels the sensation of heat and pungency. Capsinoids also stimulate TRPV1 receptors, but their effect is primarily on receptors in the throat and gut, not the mouth. Owing to the structural differences from capsaicin, the capsinoids are unable to reach the TRPV1 receptors on the tongue, which are located slightly below the mucosal surface. As a result, capsinoids do not produce the oral sensation of heat or the pungent taste associated with chili peppers, but they do produce the capsaicin-like SNS response once they bind to TRPV1 receptors in the throat and gut.
The capsinoids have multiple biological functionalities. The sports nutrition properties are directly linked to their use in energy manipulation. The capsinoids have three principal mechanisms of action. First, they up-regulate UCP-3 (Mitcohondrial Uncoupling Protein-3) in muscle cells. This causes ATP production to be dissociated with the respiration occurring in the mitochondria. This energy is then released as heat: an effect that is mirrored in caloric restriction as a means to economize energy. Second, they up-regulate UCP-1 (Uncoupling Protein-1, aka Thermogenin). This protein is only expressed in brown adipose tissue and is used to generate non- shivering thermogenesis; a process that evolved to protect against hypothermia. The up-regulation of UCP-1 can positively affect fat utilization and improve insulin sensitivity of tissues. Third, the capsinoids stimulate lipolysis via hydrolysis of triglycerides into glycerol plus three fatty acids. The release of these free fatty acids into the circulation is key to the energy regulating properties of the compound. Allowing these to become readily available as energy sources during exercise means that oxidation of muscle glycogen can be delayed, resulting in significant improvements in endurance.
Grains of Paradise Extract (12.5% 6-paradol)
Aframomum melegueta, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (Zingiberaceae) family. While complete compositional analysis have not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol.
Along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.
In the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.
Pro-GBB™ (Gamma Butyrobetaine Ethyl Ester HCL):
Core SHRED is using the trademarked form of Gamma Butyrobetaine Ethyl Ester HCL, or GBB for short, Pro-GBB™. GBB is a naturally occurring molecule in the body that aids in the boosting of the non-essential amino acid L-carnitine. L-carnitine plays a key role in energy production by its ability to transport fatty acids into the cell’s mitochondria (‘energy producing powerhouse’) to be used for energy. Studies have shown that when GBB is present it can increase the bodies L-carnitine supply, thus providing enhanced benefits. So, in simplified terms, GBB increases usable L-carnitine in the body which increases the mitochondria’s ability to use fatty acids for energy. With the goal of reducing body fat or even improving performance, L-carnitine shows particular benefits in this field. A study conducted on mammals looked at the responses of L-carnitine supplementation on growth performance as well as circumference measurements. The results showed that weights of muscle tissue increased, whereas abdominal fat percentage decreased.
SEAR - Non-Stimulant Thermogenic and Recomposition Agent
Sinetrol® XPur [blend of Grapefruit (Citrus paradise L.) (fruit), Guarana (Paullinia cupara Kunth) (seed), Sweet Orange and Blood Orange (Citrus sinesis L. Osbeck) (fruit Extracts)]:
Metabolism involves the chemical reactions that break down the foods we eat into separate compounds. Sugars, fats, and amino acids provide our body with energy to function on a daily basis. These compounds can help our body carry out many functions but when overconsumed they get stored as energy in specific adipose (fat) cells. These cells make up our fatty tissue and can further be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). The color of brown fat is due to a larger number of mitochondria being present in those tissues. Mitochondria are the energy producing structures of the cells. Most of our body’s fat is WAT, which stores energy, and when to much WAT builds up the outcome is obesity. This can also be characterized as an enlargement in adipocyte size that results from increased triglyceride storage. Brown adipose tissue, or BAT, on the other hand breaks down blood sugar (glucose) and fat molecules into usable forms of energy, mainly to create heat and maintain body temperature (homeostasis). The ratio between these two adipose tissue types determines the level of energy expenditure, which is unbalanced in those who have more body fat. Research has been centered around finding optimal ways to tap into BAT’s ability to improve obesity, and other metabolic issues.
Sinetrol® is a unique blend of citrus polyphenols that are specifically meant to target body fat mass and improve long term body composition. These citrus polyphenols have been shown to enhance the physiological energetic pathways that influence lipolysis, destoring fat that has been accumulated within white adipose cells. This process occurs at the adipocyte level, helping to reach a balance between energy storage and usage, through a process of browning of adipocytes. Sinetrol® enhances the bodies physiological lipolysis process through phosphodiesterase (PDE) inhibition. This inhibition causes the rate of cyclic adenosine monophosphate (cAMP) to be maintained at sufficient levels, which is needed to enhance the baseline lipolysis yield. This process does two things. First, it can increase lipase activity, which is essential for breaking off fatty acids from triglycerides. Second, it can stimulate an increase in the number of mitochondria in your adipose tissue (mitochondrial myogenesis), thus giving your adipose tissue a brown color in appearance. In addition to this browning process, a protein called UPC-1 (uncoupling protein) is also increased. Studies have shown that it is through these primary mechanisms of action that Sinetrol® exhibits the benefit of enhancing lipolytic rate and browning of adipocytes, leading to increased thermogenesis and utilization of fatty acids and sugars as usable forms of energy.
MitoBurn™ (L- β-Aminoisobutyric Acid):
In recent studies, MitoBurn™ (L-BAIBA), a metabolite of L-valine, has the ability to stimulate certain “exercise factors” that are released from skeletal muscle in response to muscular stress, in particular muscle contraction. L-BAIBA, a powerful myokine, plays a role in the benefits of regular exercise and begins a positive sequence of events, some of which include increased fatty acid oxidation, improved glucose uptake, and reduced fat mass. Although L-BAIBA primarily works to initiate the “browning” of adipose tissue, it also has been shown to decrease the “beiging” of adipose tissue. This beiging process is when the body reverses the preferred adipose tissue color of brown (high energy usage) back to white (high energy storage). Although most studies have been completed in rats, some results that have been obtained in cell culture models and human cohorts and shown a novel function to support L-BAIBA’s involvement in regulation of carbohydrate and lipid metabolism. These studies also support that L-BAIBA primarily exhibits its benefits in conjunction with physical activity. This is shown from skeletal muscle myokines (peptides) that play an important role is the processes listed above. These myokines are produced, expressed, and released by muscle fibers when under forceable contractions and exert both local and pleiotropic effects. Myokines also help to configure the immune-metabolic factor interactions and health promoting effects of physical exercise that stimulate the communication between skeletal muscle and adipose tissue. Adipose tissue itself will release proinflammatory cytokines in response to inactivity and can be a leading reason for the development of metabolic diseases.
This supported research of MitoBurn™ (L-BAIBA) and its benefits show that through its myokine activity and communication through physical activity as well as its ability to aid in the browning of adipose tissue, lead it to be a proposed beneficial intervention for the purposes of body composition improvements.
Coleus forskohlii Extract (root) (20% forskolin):
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SEAR!
Paradoxine® Grains of Paradise (std. to 12.5% 6-Paradol):
Aframomum melegueta, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (Zingiberaceae) family. While complete compositional analysis has not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol. 6-paradol acts as a lock and key mechanism to work along side the mechanisms of action of the other ingredients found in Core Sear.
Paradoxine® specifically is an ethanol extract of Grains of Paradise. Studies have shown that this extract can increase energy expenditure through its browning of fat tissue (similar to Sinetrol® and Mitoburn™).
Also, along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.
In the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.
split
SHRED - Non-Stimulant Thermogenic Powder
SEAR - Non-Stimulant Thermogenic and Recomposition Agent
BURN - Thermogenic Powder
- Core BURN Powder Australian Raspberry Chews Label
- Core BURN Powder Apple Guava Label
- Core BURN Powder Watermelon Grape Label
- Core BURN Powder Sour Candy Label
