The gut, or gastrointestinal (GI) tract is one of the largest systems responsible for keeping our body in working order. Food and a wide variety of nutrients pass through the separate parts, being broken down and absorbed only to be shuttled to their final destination to begin to do their job. In addition to this food, countless numbers of microorganisms from the environment pass through the gut – some of which may be detrimental to health and alter the integrity of the GI tract. Core GUT was formulated to provide all around GI tract support with beneficial bacteria in a custom probiotic blend, a useable form of food for these microorganisms in a prebiotic, beneficial by-products in a post biotic, and digestive enzymes to aid in the breakdown of crucial nutrients. This combination of ingredients has been shown to support the growth of healthy gut bacteria*, enhance immune function*, provide support for gut lining integrity*, and display protective effects on gut environment*.

Bifidobacterium 8.5 billion CFU

Bifidobacterium are labeled as probiotics and normally live in the intestines and stomach. They are essential for helping your body perform essential functions such as digestion and fighting off harmful bacteria. There are a wide range of Bifidobacterium as well so we will outline each individually below.

Bifidobacterium breve (2 billion CFU)

• One of the most helpful probiotic bacteria in the human body. Widely used probiotic strain for pediatrics. Is widely present in the gut of breast-fed infants and is known to protect against human pathogens. Some other functions of B. breve are to ferment sugars, and to product lactic acid and acetic acid. Healthy amounts of this strain can improve gut related issues such as diarrhea, gas, allergies, and irritable bowel syndrome (IBS)

Bifidobacterium infantis (2 billion CFU)

• This specific probiotic strain that is often used to alleviate irritable bowel syndrome as well as general abdominal discomfort and bloating.

Bifidobacterium bifidum (2 billion CFU)

• Bifidobacterium bifidum has shown promise in improving irritable bowel syndrome (IBS) constipation, lung infections, ulcerative colitis, diarrhea, and certain intestinal infections. One human study in 2011 on the benefits towards IBS showed that significant relief was reported with the administration of B. bifidum when placed against placebo. You can find this specific bacterium in foods like yogurt with added cultures, kefir, buttermilk, cured meats, sourdough bread, and sauerkraut.

Bifidobacterium longum (2 billion CFU)

• Bifidobacterium longum is classified as a multifunctional probiotic strain that has been shown to be highly effective in alleviating GI distress, immunological and infectious diseases. These benefits have been shown to be attributed to its ability to stabilize the gut microbiota and improve the overall intestinal environment.

Bifidobacterium lactis (500 million CFU)

• Lactic acid bacteria are among the most populated microflora that live within the human large intestine. They are believed to be play an integral role in the homeostasis of the gut microbiome as well as are highly beneficial for overall health. This specific Bifidobacterium can be found in many yogurts, cheeses, and other fermented dairy products and can possess benefits ranging from improved digestion, increased uptake of dietary minerals, reduction in cholesterol, as well as improvements in natural immunity.

Lactobacillus 16.5 billion CFU

As arguably the most common probiotic group, Lactobacillus can aid the body in the breakdown of foods, absorption of key nutrients, and defend against destructive organisms that can cause distress and other diseases.

Lactobacillus acidophilus (4 billion CFU)

• One of the most common probiotic types that can be most commonly found in many fermented foods, and added to yogurts, and cheeses. This type of bacteria is found in the intestines and plays a vital role in boosting human health. This bacterium helps produce lactic acid. It goes through a process of producing an enzyme called lactase, which helps break down lactose into lactic acid. This bacterium has been extensively studied for its benefits of alleviating symptoms pertaining to IBS, diarrhea, bloating, and other GI distress.

Lactobacillus plantarum (2 billion CFU)

• L. plantarum has a significant importance on boosting antioxidant activity as well as helping maintain intestinal permeability. It can work to suppress the growth of bacteria that produce gases in the intestines as well as benefit some who suffer from IBS.

Lactobacillus bulgaricus (2 billion CFU)

• L. bulgaricus has been used mostly as a probiotic to help aid in the improvements of digestion, prevent diarrhea, and to relieve symptoms associated with IBS. Alongside L. acidophilus it has the potential to work by helping the body maintain normal consistency of the bacteria living in the stomach and intestines.

Lactobacillus casei (2 billion CFU)

• Naturally found in the gut as well as some fermented foods, L. casei has been shown to positively regulate our digestive system by contributing to the reduction of diarrhea. It can also positively impact constipation, Crohn’s disease, inflammatory bowel disease (IBD), IBS, lactose intolerance, and ulcerative colitis.

Lactobacillus rhamnosus (2 billion CFU)

• L. rhamnosus is able to promote immune-responsiveness by reducing the expression of several activation and inflammation markers on monocytes and by increasing the production of interleukin in macrophages. It produces a biofilm that can protect the mucosa and also produces soluble fibers that are beneficial to the gut.

Lactobacillus brevis (2 billion CFU)

• L. brevis is a type of lactic acid bacteria found in milk-based products, fermented products, and in some plants as they decompose. Its benefits include alleviating diarrhea related symptoms in children and supporting natural killer (NK) cell activity in older individuals. These NK cells are a type of pathogen-killing cell that can fight off infections and stop the growth of cancerous cells.

Lactobacillus gasseri (500 million CFU)

• L. gasseri is a unique strain of bacteria commonly found in the genital, urinary, and digestive systems of the body. It possesses many benefits but it has shown particular promise in aiding positive changes in weight and improvements in body composition. It has also shown promise in reducing blood and liver cholesterol, and reducing oxidative stress in the body. These benefits are most likely attributed from reduced inflammatory status present in adipose tissue.

Lactobacillus fermentum (500 million CFU)

• L. fermentum has been reported to enhance immunologic response as well as prevent community-acquired GI and upper respiratory infections. This specific strain of Lactobacillus also produces potent antimicrobial peptides, which can then be used as a food preservative or as alternatives in antibiotics. It has been studied to provide the benefit of decreasing cholesterol levels in the blood stream and to potentially prevent alcoholic liver disease and colorectal cancer in humans.

Lactobacillus reuteri (500 million CFU)

• This well studied strain of Lactobacillus can colonize a large number of mammals and provide essential benefits. Found in the GI tract, urinary tract, skin, and breast milk, the benefits of this strain include the production of antimicrobial molecules that can inhibit the colonization of pathogenic microbes and strengthen the microbiota composition of its host. Other benefits include enhancing the immune system through the production of pro-inflammatory cytokines while promoting regulatory T-cell development and function, as well as strengthening the intestinal barrier. These T-cells help maintain intestinal homeostasis by controlling inflammation and inducing tolerance.

Lactobacillus paracasei (500 million CFU)

• As a potent strain with immune modulation properties, several studies have shown that L. paracasei can provide relief from inflammatory bowel disease as well as alleviate inflammatory symptoms associated with colitis and other colon related issues.

Lactobacillus salivarius (500 million CFU)

• This probiotic species is widely found in the GI tract of mammals and has been shown to possess benefits that include relief from IBS related symptoms, pancreatic necrosis, and atopic dermatitis. Many of these benefits come from the species ability to suppress pro-inflammatory cytokines and bacterial overgrowth in the small intestine, which leads to reduced bacterial translocation.

Saccharomyces 5 billion CFU

Saccharomyces boulardii (5 billion CFU)

• S. boulardii is a specific type of probiotic yeast that has been shown to possess benefits for human gastrointestinal health. The probiotic benefits of this organism include fighting against toxins and other harmful bacteria, increasing the function of the gut biome, providing inflammation relief for the gut lining to improve efficiency, boosting immune function, and helping to restore optimal nutrient levels, like short chain fatty acid production, for the gut. Some of the conditions that S. boulardii protects against are IBS, Crohn’s disease, Ulcerative colitis, and C. diff infections.

Tributyrin (as Core Biome™ 30% yielding 300mg)

The gut microbiome is responsible for contributions that maintain intestinal balance. Disturbances in this homeostasis can cause alterations in the metabolic and fermentation byproducts that occur in the gut. With the gut being so closely tied to many bodily processes involving many of the body’s vital systems, optimal gut health is of importance. The microbiota of the gut ferment undigested sugars to product short-chain fatty acids such as, acetate, propionate, and butyrate. Butyrate is especially essential as it has mechanisms of action that include effects of suppressing inflammation and immunoprotection, serving as the primary nutrient that provides energy to colonocytes, and regulating functions of gene expression, gut tissue development, oxidative stress reduction, and diarrhea control. When butyrate is depleted or scarce, GI distress and other injury can occur.

Several studies have looked at the effectiveness of supplemental tributyrin on the benefits of gut health and have shown promising results. One animal study combining tributyrin with essential oils concluded that this combination improved the intestinal morphological structure and positively altered the intestinal microbiota and metabolites that benefit gut health. Another animal study analyzing parameters for growth as it pertains to performance of the gut microbiota concluded that, with the addition of tributyrin, there was an enhanced potential for energy metabolism and indicated that tributyrin can promote changes in the gut microbial communities. These positive changes seen can contribute to improving animal performance after weaning from an infant diet to an adult diet.

Several human studies have also looked at tributyrin’s positive role on the body. Most of these studies have involved tumors of some sort, but this does provide promise to the potential benefits it can have when tumors are not present as increases in immunoprotection can beneficial for everyone. One human study showed that tributyrin was able to be cytostatic to cancer cells and induce differentiation and apoptosis (cell death) to colon cancer cells through the stimulation of interleukin-2 and -12 (2 cytokine signaling molecules in the immune system).

While more studies can be beneficial for solidifying tributyrin’s benefits on gut health, these current studies do show its ability to provide immunoprotection and boost the overall function of the vital gut microbiome. CoreBiome® has been clinically proven to be a highly bioavailable source of this vital nutrient.

Sunfiber® Guar Fiber

Sunfiber®, a fermented, dietary fiber, is a proven prebiotic fiber that increases both Bifidobacteria and Lactobacillus levels with the aim of providing digestive support. These beneficial bacteria promote a healthy gut microbiota and aim to enhance the overall function of the gut, thus leading to increased function of the other vital systems of the human body. Fermentation of Sunfiber® by the gut microbiome results in production of short-chain fatty acids such as butyrate, which as we discussed above, provides valuable energy for the digestive tract. The other benefits of this prebiotic include increasing the absorption of important macronutrients and vital minerals, increasing satiety and appetite control, regulating blood glucose levels, improving IBS related symptoms, and providing stool regularity.

Digestive Enzyme Blend (Protease, Lactase, Amylase, Lipase)

One can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).

Despite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products.

As usual, we take a much more comprehensive, clinical approach than the average. In Core Life Line’s Gut product, we have included a digestive enzyme blend comprised by:

• Proteases- breaks down proteins and other peptides
• Lactases- breaks down lactose
• Amylases- breaks down starches into useable sugars, such as glucose and maltose
• Lipases- breaks down fats/lipids which allow for a full and complete breakdown of all of your daily dietary components.

• GUT Label

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