COMPREHENSIVE KIDNEY SUPPORT'

Go-Less®: A blend of pumpkin seed extract and soy germ extract to promote healthy kidney and bladder function.
Goldenrod Extract: : Renowned for its diuretic, anti-inflammatory, and antimicrobial properties to support a healthy urinary system.
PaCran® Cranberry Extract: Helps protect against UTIs and encourages regular urinary flow.

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Go-Less® is a clinically studied blend of pumpkin seed and soy germ extracts designed to support kidney and bladder health. It promotes bladder strength and flexibility, reduces urgency, and improves overall bladder function, making it especially beneficial for individuals with overactive bladder (OAB) symptoms. Clinical studies have shown that Go-Less® helps reduce urinary frequency and urgency, leading to improved bladder control and sleep quality. The supplement also supports kidney health by aiding in detoxification and helping the kidneys efficiently filter waste and excess fluids, lowering the risk of kidney-related issues.

Goldenrod extract, a versatile herb, is known for its diuretic, anti-inflammatory, and antimicrobial properties, which help maintain a healthy urinary system and manage conditions like UTIs and kidney stones. PaCran® cranberry extract, rich in flavonoids, provides protection against UTIs by preventing the adhesion of pathogens to the urinary tract, and also reduces inflammation and supports bladder function. Other ingredients like Stinging Nettle, Grape Seed, and Astragalus extracts further support kidney and bladder health by promoting healthy urine flow, reducing oxidative stress, and enhancing immune function, making this supplement an effective, natural solution for maintaining urinary health.

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Go-Less® Proprietary Blend [Pumpkin (Curcurbita pepo) Seed Extract, Soy (Glycine max) Germ Extract]

Go-Less® is a clinically studied blend of pumpkin seed extract and soy germ extract, that has been specifically formulated to support the health and function of the kidneys and bladder. As a natural supplement, Go-Less® can offer an effective approach to managing urinary tract health, reducing time for bladder emptying, and improving overall quality of life.

To promote healthy and normal bladder function, the unique combination of pumpkin seed and soy germ extracts found in Go-Less® can work synergistically to support bladder strength and flexibility. Pumpkin seed extract is rich in essential fatty acids and phytosterols, which have been shown to improve bladder function by enhancing the tone of the bladder muscles and supporting the integrity of the bladder wall. This can help reduce the sensation of urgency and the frequency of urination, making it especially beneficial for individuals dealing with overactive bladder (OAB) symptoms.

Clinical studies have demonstrated the effectiveness of Go-Less® in improving bladder health. One study published in Urology found that participants who took Go-Less® experienced a significant reduction in daytime and nighttime urinary frequency, as well as a decrease in urgency episodes. This improvement in bladder control was attributed to the supplement’s ability to strengthen the bladder muscles and reduce bladder pressure, leading to fewer interruptions in daily activities and better sleep quality at night.

Go-Less® also has been shown to provide support for kidney health, an essential aspect of maintaining overall urinary system function. The kidneys play a critical role in filtering waste and excess fluids from the blood, and their proper function is vital for maintaining electrolyte balance and blood pressure. The natural compounds in Go-Less® can help support the kidneys’ detoxification processes, ensuring they operate efficiently and reducing the risk of developing kidney-related issues.

In addition to its direct benefits for bladder and kidney health, Go-Less® also offers a natural alternative for those seeking to manage urinary health without the side effects associated with pharmaceutical options. The ingredients in Go-Less® are 100% plant-based and have shown to be well-tolerated by users, making it a safe option for long-term use in those who are affected by bladder and kidney related issues. This is particularly important for individuals with chronic urinary issues or those looking to maintain their urinary health as they age.

As the backbone in our KIDNEY Lifeline product, Go-Less® can provide comprehensive support for kidney and bladder health through a combination of clinically proven ingredients. By promoting bladder strength, reducing urinary frequency, and supporting kidney function, Go-Less® offers a natural and effective solution for individuals seeking to improve their urinary health and enhance their overall quality of life. So, whether you're looking to manage the symptoms of an overactive bladder or simply looking to maintain healthy kidney function, Go-Less® is a trusted option backed by clinical research to support its benefits.

Goldenrod Extract 10:1 (Solidago decurrens Lour) (Whole Plant)

Goldenrod (Solidago virgaurea) is a versatile herb that has been used for centuries in traditional medicine to support kidney and bladder health. Most notably used for its diuretic, anti-inflammatory, and antimicrobial properties, Goldenrod can be a suitable choice for those looking to maintain a healthy urinary system and manage conditions such as urinary tract infections (UTIs) and kidney stones.

One of the primary benefits of Goldenrod is its diuretic effect, which promotes healthy urine flow and can help flush out toxins and other waste products from the kidneys. This increased urine output can be particularly beneficial for preventing the formation of kidney stones by reducing the concentration of minerals and salts in the urine that can lead to stone formation.

In addition to its diuretic properties, Goldenrod is known for its anti-inflammatory and antimicrobial effects, which can help manage and prevent urinary tract infections (UTIs). UTIs are often caused by bacteria that find a home within the urinary tract, leading to discomfort, pain, and frequent urination. Goldenrod contains compounds such as saponins and flavonoids, which have been shown to inhibit the growth of harmful bacteria and reduce inflammation in the urinary tract. Several studies have demonstrated that Goldenrod extract exhibits strong antimicrobial activity against common UTI-causing bacteria, such as E. coli, and other harmful bacteria. By combating bacterial growth and soothing inflammation, Goldenrod can aid in the alleviation of UTI symptoms and support the body's natural defenses against infection.

Goldenrod can also offer support for overall bladder health, particularly in managing conditions like overactive bladder (OAB) and bladder inflammation. Again, its anti-inflammatory properties can help reduce irritation in the bladder, while its diuretic action can ensure that the bladder is regularly flushed, preventing the buildup of irritants that can trigger OAB symptoms. Goldenrod’s ability to strengthen and tone the urinary tract muscles can contribute to better bladder control, reducing the frequency and urgency of urination.

PaCran® Cranberry Extract

Cranberry (Vaccinium macrocarpon), a rich and distinctive source of flavonoids and phenolic acids, has been often utilized to protect against urinary tract infections (UTIs), the second most common type of infection worldwide. These infections, as we have discovered above, are often triggered from the exposure of unwanted bacterium, most notably E. coli, and can lead to significant issues that not only affect internal organs, but also can negatively affect overall quality of life. Cranberry’s being rich is flavonoids, particularly proanthocyanidins, anthocyanidins, and flavanols, along with other phenolic acids and benzoates, provide some key mechanisms of action for their protective effects. These flavonoids have been shown to act as antiadhesive agents in preventing/inhibiting the adherence of pathogens to uroepithelial cell receptors, which appear to be a major component in the pathogenesis of UTIs.

PaCran® is a clinically studied cranberry extract specifically designed to support overall kidney and bladder health. Unlike other traditional cranberry products, PaCran® combines the full spectrum of cranberry's beneficial compounds mentioned above, which are known for their ability to promote healthy urinary tract function and aid in the prevention of infection. One study looking at the effects of cranberry ingestion on urinary health demonstrated that women who supplemented with a cranberry extract rich in PACs experienced a significant reduction in the recurrence of UTIs. This data suggests that PaCran® can be an effective preventive measure for those prone to recurrent UTIs.

In addition to its role in preventing infections, PaCran® also supports overall bladder health by reducing inflammation and promoting regular urinary flow. The anti-inflammatory properties of cranberry help soothe the urinary tract, reducing irritation and discomfort that can be caused by infections or other urinary conditions. By promoting healthy bladder function, PaCran® can help to maintain a comfortable and efficient urinary flow, reducing the frequency and urgency of urination often associated with bladder irritation or overactive bladder (OAB).

PaCran® also can offer benefits for kidney health. The potent antioxidant properties of PaCran® can help protect the kidneys from high amounts of oxidative stress, which can lead to cellular damage and impair kidney function over time. By neutralizing free radicals, PaCran® can support the kidneys' ability to efficiently filter and eliminate toxins, contributing to long-term kidney health.

Backed by several human clinical studies, PaCran® is a natural and well-tolerated supplement, making it a safe option for long-term use in maintaining urinary health. It offers a more convenient and concentrated form of cranberry's benefits without the high sugar content often found in cranberry juice, making it an ideal choice for individuals looking to manage their urinary health naturally and effectively.

Stinging Nettle Extract (Urtica dioica) (Root) (20:1)

Stinging nettle has been widely used in traditional medicine for its benefits as a diuretic and to treat things like joint pain, eczema, arthritis, gout, and anemia. More recently, stinging nettle has been utilized for the purpose of maintaining normal urinary flow and contributing to a healthy, optimal functioning prostate. Stinging nettle has also shown effectiveness when used in combination with other herbs, like saw palmetto (included above). Human studies have shown this effectiveness in these areas, like urinary flow maintenance, through their specific mechanisms of action, which were discussed in the paragraph above.

Grape Seed Extract (Vitis vinifera) (Seed) (Std. to 95% Proanthocyanidins)

Grape seed extract, a powerful, antioxidant rich compound derived from the seeds of grapes, often utilized for it benefits for cardiovascular health, also has been shown to offer significant benefit for the kidneys and bladder. Primarily through its ability to combat oxidative stress, reduce inflammation, and promote overall urinary tract function, grape seed extract can be a beneficial compound to support these areas.

Grape seed extracts primary benefits for kidney health lies in its potent antioxidant properties. The kidneys are constantly exposed to oxidative stress as they filter toxins and waste products from the blood. Over time, this exposure can lead to cellular damage, contributing to the development of chronic kidney disease (CKD) and other kidney-related issues. The proanthocyanidins found in grape seed extract have been shown to neutralize free radicals and protect kidney cells from excessive oxidative damage.

In addition to its antioxidant effects, grape seed extract also has inflammatory mitigating properties that benefit both the kidneys and bladder. Chronic inflammation is a common factor in many urinary tract issues, including interstitial cystitis (IC) and other forms of bladder irritation. Grape seed extract has been shown to reduce inflammation by inhibiting the production of pro-inflammatory cytokines and enzymes, such as COX-2.

Grape seed extract may also play a role in protecting against urinary tract infections (UTIs). The antimicrobial properties of grape seed extract, combined with its ability to strengthen the bladder lining, can help create an environment that is less favorable for bacterial growth.

Astragalus Extract (Astragalus membranaceous) (Root) (Std. to 50% Polysaccharides)

Astragalus extract (Astragalus membranaceous) has been shown to offer powerful benefits for overall urinary system health. Polysaccharides, the active compounds in Astragalus, are known for their immune-boosting, anti-inflammatory, and potent antioxidant properties.

One of the primary benefits of Astragalus extract for kidney health is its ability to protect against renal damage and support kidney function. The polysaccharides contained within Astragalus have been shown to reduce proteinuria, which is the presence of excess protein in the urine. This can be a common sign of kidney damage, particularly in conditions like chronic kidney disease (CKD).

The antioxidant properties of Astragalus polysaccharides can further enhance kidney protection by combating oxidative stress, which is a major contributor to kidney damage.

Setria® Glutathione

Glutathione is an amino acid containing molecules of L-glutamic acid, L-cysteine, and Glycine that is particularly concentrated in the liver. The liver has a unique ability to synthesize cysteine, a glutathione precursor, from endogenous sources through the trans-sulphuration pathway or through protein breakdown and food. It is vital to many different properties and is best known for being a powerful antioxidant.

AstraGin® (Astragalus membranaceus and Panax notoginseng Root Extracts)

AstraGin® is a patented blend of natural extracts derived from Astragalus membranaceus and Panax notoginseng. While it is most widely recognized and utilized for its role in enhancing nutrient absorption, AstraGin® can also offer significant benefits for overall kidney and bladder health.

BioPerine® (Piper nigrum) (Fruit) (Std. to 95% piperine)

BioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.

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Unflavored Label

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REFERENCES

Bongseok Shim, Hyewon Jeong, Sara Lee, Sehee Hwang, Byeongseok Moon, Charlotte Storni, A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life, Journal of Functional Foods, Volume 8, 2014, Pages 111-117, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2014.03.010.

Kidney